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KMID : 0376219650020010021
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Chonnam Medical Journal
1965 Volume.2 No. 1 p.21 ~ p.31
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Experimental Studies on RES Function
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Abstract
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To investigate the RES function in liver, spleen, bone marrow, adrenal gland, kidney and blood, the iodine-131-labelled-Collargol (RES blocking agent) was injected into normal rabbits and its radionctivity in earh organ hourly for 20 days was measured. The histological investigation was also carried out in each organ by ordinary histological method and microautoradiography.
A. The RES function in each organ measured by radioactivity :
1. The RES blocking agent injected into the vein disappeared from the blood stream in a short time and phagocyted in spleen, liver and bone marrow.
2. Comparison of the distribution curves of tile phagocyted agent revealed phagocytic activity in the order of liver, bone marrow, spleen and adrenal gland, when total weight of each organ was considered. However, the amount of the agent phagocyted in the unit weight of organs revealed phagocytic activity in the order of bone marrow, spleen, liver and adrenal gland. Thus, the phagocytic power of bone marrow was found to be competent with liver and spleen in the unit freight of each organ.
3. During first three days, there appeares to be no remarkable changes in the amount of blocking agent phagocrted in RES. After then, gradual disappearance of the agent was observed. In the spleen and bone marrow it disappeared more slowly than in the liver. Bone marrow retained molt of the agent until the last day of this experiment.
4. The disappearance of the blocking agent in the kidney was rapid as
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